Long acting insulin glargine overdose, a surprising long lifetime
نویسندگان
چکیده
منابع مشابه
Insulin glargine: a long acting insulin analog.
The main goal of treatment of diabetes mellitus (DM) is to maintain long term near normoglycemia. Insulin therapy plays a pivotal role in the management of DM. Most insulin preparations and insulin delivery systems, do not mimic the physiological insulin secretion in the body, leading to impaired metabolic control and increased hypoglycemic attacks. Insulin glargine is newer, long acting insuli...
متن کاملInsulin glargine: a long-acting insulin for diabetes mellitus.
Insulin glargine is a once-daily, biosynthetic, human insulin analogue. Some trials show that in patients with type 1 diabetes mellitus, insulin glargine offers an advantage in blood glucose control compared with NPH insulin. There is some evidence of decreased nocturnal and symptomatic hypoglycemia in patients receiving insulin glargine compared with those receiving NPH insulin, but there are ...
متن کاملMassive Levemir (Long-Acting) Insulin Overdose: Case Report
A 52-year-old insulin-dependant diabetic man presented to the Emergency Department 2 hours after a deliberate massive overdose of 2100 units of long-acting Levemir insulin and a large quantity of whisky. On initial assessment, his GCS was 3/15 and his capillary blood sugar was 2.6 mmol/L. The patient was given a 50 ml bolus of 50% dextrose, followed by intravenous infusions of both 5% and 10% d...
متن کاملSystematic review and economic evaluation of a long-acting insulin analogue, insulin glargine.
OBJECTIVES To evaluate the use of insulin glargine in its licensed basal-bolus indication in terms of both clinical and cost-effectiveness. DATA SOURCES Electronic databases. REVIEW METHODS A systematic review of the literature, involving a range of databases, was performed to identify all papers relating to insulin glargine. RESULTS Nineteen studies met the inclusion criteria but full re...
متن کاملLong-Acting Human Insulin Analogs
Endogenous insulin is a hormone secreted by the beta cells of the pancreatic islets of Langerhans. Insulin acts via specific membrane-bound receptors on target tissues to regulate metabolism of carbohydrates, proteins and fats. Exogenous insulin, manufactured for pharmacologic use through recombinant DNA technology using either E. coli or Saccharomyces cerevisiae is used as replacement therapy ...
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ژورنال
عنوان ژورنال: Toxicology Communications
سال: 2019
ISSN: 2473-4306
DOI: 10.1080/24734306.2019.1583307